List of Publicly Traded Small-Cap Biotech Companies Listed on Major U.S. Exchanges
This list includes small-sized biotech companies with market capitalizations between 250 million and one billion dollars. We update this page at the start of every month so it is possible that during the course of a month a company’s market cap might fall below 250 million or go above one billion. In parentheses you will find a short description or areas of focus for the company.
There have been a number of initial publicly offerings (IPOs) in this category during the course of 2015. Here is a list of these biotech small-cap IPOs:
Recent Small-Cap Biotech IPOs in 2015
Adaptimmune Theapeutics plc (ADAP) (United Kingdom, biopharmaceutical company: cancer immunotherapy products)
Aimmune Therapeutics, Inc. (AIMT) (Biopharmaceutical company: allergies)
aTyr Pharma Inc. (LIFE) (Medicines used in the treatment of severe rare diseases)
Blueprint Medicines Corporation (BPMC) (Biopharmaceutical company: kinase inhibitors for genomically defined cancers)
Cellectis SA (CLLS) (Gene-editing company: cancer therapies based on engineered T cells)
Celyad SA (CYAD) (Cell therapy treatments; cardiovascular disease, oncology)
Chiasma Inc. (CHMA) (Biopharmaceutical company: oral versions of injected drugs for orphan diseases)
CytomX Therapeutics Inc. (CTMX) (Biopharmaceutical company; antibody therapeutics, oncology)
Dimension Therapeutics Inc. (DMTX) (Gene therapy platform company: rare diseases associated with the liver)
Edge Therapeutics Inc. (EDGE) (Neurological conditions)
Nantkwest Inc. (NK) (Immunotherapy company: cancer)
ProNAi Therapeutics Inc. (DNAI) (Oncology company: therapeutics based on their DNA interference technology platform)
Regenxbio Inc. (RGNX) (In vivo gene therapy products designed to treat various diseases)
Xbiotech Inc. (XBIT) (Biopharmaceutical company: cancer antibodies)
Select the company’s link to view profiles, charts, company website information or news links for the selected company.
Biotech: Small-Cap Stocks
Acceleron Pharma Inc. (XLRN) (Cancer and orphan diseases)
Agenus Inc. (AGEN) (Immunology: cancer, infectious diseases)
Atara Biotherapeutics, Inc. (ATRA) (Molecularly-targeted product candidates and T-cell product candidates; cancer, kidney disease and other illnesses)
BioSpecifics Technologies Corp (BSTC) (Biopharmaceutical company: injectable collagenase used for treatment of Dupuytren’s contracture and Peyronie’s disease)
ChemoCentryx, Inc. (CCXI) (Biopharmaceutical company: orally-administered therapeutics for the treatment of autoimmune diseases, inflammatory disorders and cancer)
Concert Pharmaceuticals, Inc. (CNCE) (CNS disorders, renal disease, inflammation and cancer)
Five Prime Therapeutics, Inc. (FPRX) (Protein therapeutics)
Geron Corporation (GERN) (Biopharmaceutical company: telomerase inhibitor in hematologic myeloid malignancies)
Inovio Pharmaceuticals, Inc. (INO) (Cancer, infectious diseases, vaccines)
La Jolla Pharmaceutical Company (LJPC) (Biopharmaceutical company: therapies for patients suffering from life-threatening diseases)
PDL BioPharma, Inc. (PDLI) (Patents and royalty assets: antibody humanization patents)
Sangamo BioSciences, Inc. (SGMO) (Biopharmaceutical company: infectious diseases, monogenic diseases, hemoglobinopathies)
Vitae Pharmaceuticals, Inc. (VTAE) (Treatment of diseases with unmet medical needs; acute coronary syndrome, Alzheimer’s disease, atopic dermatitis, autoimmune disorders, diabetes)
Biopharmaceutical Companies: Diversified
Omeros Corporation (OMER) (Biopharmaceutical company: small-molecule and protein therapeutics targeting inflammation, coagulopathies and disorders of the central nervous system)
Regulus Therapeutics Inc. (RGLS) (Biopharmaceutical company: microRNA therapeutics for oncology indications and orphan diseases)
Relypsa, Inc. (RLYP) (Biopharmaceutical company: polymeric medicines)
Sucampo Pharmaceuticals, Inc. (SCMP) (Biopharmaceutical company: drug approved for the treatment of CIC in adults and OIC in adults with chronic, non-cancer pain)
Theravance Biopharma, Inc. (TBPH) (Biopharmaceutical company: diseases of the lung, gastrointestinal tract, infectious diseases)
Trevena, Inc. (TRVN) (Biopharmaceutical company: discovery and development of GPCR biased ligands)
Allergies
Aimmune Therapeutics, Inc. (AIMT) (Biopharmaceutical company: allergies)
Antibody
Xencor, Inc. (XNCR) (Antibody therapeutics: autoimmune disorders, asthma and allergic diseases, cancer)
Biosimilars
Pfenex Inc. (PFNX) (Non-glycosylated biosimilars)
Cancer
Adaptimmune Theapeutics plc (ADAP) (United Kingdom, biopharmaceutical company: cancer immunotherapy products)
Array BioPharma Inc. (ARRY) (Biopharmaceutical company: targeted small molecule drugs used to treat patients afflicted with cancer)
Bellicum Pharmaceuticals, Inc. (BLCM) (Biopharmaceutical company: cellular immunotherapies for various forms of cancer; hematological and solid tumors, orphan inherited blood disorders)
Blueprint Medicines Corporation (BPMC) (Biopharmaceutical company: kinase inhibitors for genomically defined cancers)
Cellectis SA (CLLS) (Gene-editing company: cancer therapies based on engineered T cells)
Compugen Ltd. (CGEN) (Israel: immuno-oncology programs which are aimed at harnessing the immune system to eradicate cancer)
CTI BioPharma Corp. (CTIC) (Biopharmaceutical company: therapies covering a spectrum of blood-related cancers)
Curis, Inc. (CRIS) (Drug candidates for the treatment of human cancers)
CytomX Therapeutics Inc. (CTMX) (Biopharmaceutical company; antibody therapeutics, oncology)
Epizyme, Inc. (EPZM) (Biopharmaceutical company: therapeutics for patients with genetically defined cancers)
Galena Biopharma, Inc. (GALE) (Biopharmaceutical company: oncology therapeutics across the full spectrum of cancer care)
Ignyta, Inc. (RXDX) (Oncology biotechnology company)
Immune Design Corp. (IMDZ) (Immunotherapy company)
ImmunoGen, Inc. (IMGN) (Tumor-targeting antibodies to deliver a cell-killing agent specifically to cancer cells)
Infinity Pharmaceuticals, Inc. (INFI) (Biopharmaceutical company: (Blood cancers, indolent non-Hodgkin lymphoma, chronic lymphocytic leukemia)
Lion Biotechnologies, Inc. (LBIO) (Immunotherapies based on tumor infiltrating lymphocytes)
Loxo Oncology, Inc. (LOXO) (Cancer therapies)
Mirati Therapeutics, Inc. (MRTX) (Oncology company: genetically-targeted oncology therapeutics)
Nantkwest Inc. (NK) (Immunotherapy company: cancer)
Northwest Biotherapeutics, Inc. (NWBO) (Cancer vaccines designed to treat a broad range of solid tumor cancers)
OncoMed Pharmaceuticals, Inc. (OMED) (Biopharmaceutical company: antibody therapeutics targeting cancer stem cells)
Oncothyreon Inc. (ONTY) (Oncology products; developing small molecules and therapeutic vaccines)
Progenics Pharmaceuticals Inc. (PGNX) (Oncology company: diagnostic and therapeutic needs of prostate cancer patients)
ProNAi Therapeutics Inc. (DNAI) (Oncology company: therapeutics based on their DNA interference technology platform)
Sorrento Therapeutics, Inc. (SRNE) (Oncology company: treatments for cancer and associated pain)
Spectrum Pharmaceuticals, Inc. (SPPI) (Hematology, oncology)
Threshold Pharmaceuticals, Inc. (THLD) (Therapeutic agents that selectively target tumor cells)
Tokai Pharmaceuticals, Inc. (TKAI) (Therapies for cancer; prostate cancer)
Xbiotech Inc. (XBIT) (Biopharmaceutical company: cancer antibodies)
Cellular Therapy
Celyad SA (CYAD) (Cell therapy treatments; cardiovascular disease, oncology)
Children
Retrophin, Inc. (RTRX) (Biopharmaceutical company: catastrophic diseases affecting children)
Cystic Fibrosis
ProQR Therapeutics N.V. (Cystic fibrosis and severe genetic disorders)
EARS
Otonomy, Inc. (OTIC) (Biopharmaceutical company: therapeutics for the treatment of diseases and disorders of the ear)
Endocrine Disorders
Versartis, Inc. (VSAR) (Biopharmaceutical company: treatment of endocrine disorders)
Gastrointestinal
Ardelyx, Inc. (ARDX) (Molecule therapeutics: gastrointestinal)
Synergy Pharmaceuticals, Inc. (SGYP) (Biopharmaceutical company: therapies for the treatment of gastrointestinal diseases and disorders)
Gene Therapy
Regenxbio Inc. (RGNX) (In vivo gene therapy products designed to treat various diseases)
Heart
Amarin Corporation Plc. (AMRN) (Ireland, biopharmaceutical company: cardiovascular health)
Infectious Disease
BioCryst Pharmaceuticals, Inc. (BCRX) (Infectious and inflammatory diseases)
Paratek Pharmaceuticals, Inc. (PRTK) (Antibiotics)
Sinovac Biotech, Ltd. (SVA) (China: Biopharmaceutical company: vaccines that protect against human infectious diseases)
Kidney
Akebia Therapeutics, Inc. (AKBA) (Biopharmaceutical company: anemia secondary to chronic kidney disease)
Keryx Biopharmaceuticals, Inc. (KERX) (Biopharmaceutical company: renal disease)
Rockwell Medical, Inc. (RMTI) (Biopharmaceutical company: end-stage renal disease and chronic kidney disease)
Liver
Arbutus Biopharma Corporation (ABUS) (Canada, biopharmaceutical company: chronic hepatitis B infection)
Arrowhead Research Corporation (ARWR) (Biopharmaceutical company: RNAi therapeutics, chronic hepatitis B infection)
Dimension Therapeutics Inc. (DMTX) (Gene therapy platform company: rare diseases associated with the liver)
Enanta Pharmaceuticals, Inc. (ENTA) (Small molecule drugs for viral infections and liver diseases)
MS
Forward Pharma (FWP) (Denmark: immunomodulatory compound dimethyl fumarate and derivatives used to treat immune disorders including multiple sclerosis and psoriasis)
Muscles
Cytokinetics, Incorporated (CYTK) (Biopharmaceutical company: debilitating diseases in which muscle performance is compromised and/or declining)
Nervous System
Edge Therapeutics Inc. (EDGE) (Neurological conditions)
Vanda Pharmaceuticals Inc. (VNDA) (Biopharmaceutical company: atopic dermatitis, Non-24-Hour Disorder, schizophrenia)
Neurological
XenoPort, Inc. (XNPT) (Biopharmaceutical company: neurological disorders, chronic plaque-type psoriasis)
Pain
Cara Therapeutics, Inc. (CARA) (Chemical entities designed to alleviate pain and pruritus)
Rare Diseases
Aegerion Pharmaceuticals, Inc. (AEGR) (Biopharmaceutical company)
Akari Therapeutics, Plc (AKTX) (United Kingdom, biopharmaceutical company: therapeutics to treat orphan autoimmune and inflammatory diseases)
Amicus Therapeutics, Inc. (FOLD) (Biopharmaceutical company: lysosomal storage diseases)
aTyr Pharma Inc. (LIFE) (Medicines used in the treatment of severe rare diseases)
Catalyst Pharmaceutical Partners, Inc. (CPRX) (Biopharmaceutical company: rare neuromuscular and neurological diseases)
Chiasma Inc. (CHMA) (Biopharmaceutical company: oral versions of injected drugs for orphan diseases)
Idera Pharmaceuticals, Inc. (IDRA) (B-cell Lymphoma, autoimmune, rare)
PTC Therapeutics, Inc. (PTCT) (Biopharmaceutical company: oral treatments)
Raptor Pharmaceutical Corp. (RPTP) (Biopharmaceutical company: nephropathic cystinosis)
Sarepta Therapeutics, Inc. (SRPT) (Biopharmaceutical company: RNA-based therapeutics; rare and infectious diseases)
UniQure N.V. (QURE) (Netherlands: gene therapy)
Regenerative Medicine
BioTime, Inc. (BTX) (Regenerative medicine to patients with serious diseases and degenerative conditions)
Osiris Therapeutics, Inc. (OSIR) (Regenerative products for wound care, sports medicine, and orthopaedics)
Skin
Dermira, Inc. (DERM) (Biopharmaceutical company: products to dermatologists and their patients)
Weight Management
Arena Pharmaceuticals, Inc. (ARNA) (Biopharmaceutical company: drugs that target G protein-coupled receptors; weight management)
Orexigen Therapeutics, Inc. (OREX) (Biopharmaceutical company: obesity)
Zafgen, Inc. (ZFGN) (Biopharmaceutical company: obesity)